Severe liver damage may occur if you take more than 4000 mg of acetaminophen in 24 hours. Take only one product that contains acetaminophen at a time. Always … The maximum daily dose of acetaminophen for a healthy adult who weighs at least 150 pounds is 4000 milligrams (mg). However, in some people, … The maximum acetaminophen dose for healthy adults is 4,000 mg in 24 hours, though many medical experts recommend a safer 3,000 mg daily cap. 2012 For Tylenol® Extra Strength, the maximum dose is 3,000 milligrams per 24 hours. You may take this medicine with or without food. For patients using the oral … Do not take more than 6 caplets in 24 hours, unless directed by a doctor. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 …