2018 2025 Examples include ibuprofen (Advil, Motrin), meloxicam (Mobic) and naproxen (Aleve). So it\’s typically safe to take these OTC pain medications with methocarbamol … There were no interactions found between methocarbamol and naproxen. However, this does not necessarily mean no interactions exist. Always consult your … 2017 Is it safe to take 1 tablet of naproxen (500 mg) and 1 tablet of methocarbamol (750 mg) for back pain at the same time? 2 doctors weighed in …